Ī high BUN/Creatinine ratio indicates an underlying disease/disorder and will usually be accompanied by the symptoms of this underlying disorder. Drugs such as acetazolamide, a diuretic used to treat various conditions including glaucoma, epilepsy, altitude sickness, and heart failure.When kidneys become impaired for any reason, creatinine blood levels will rise. Rhabdomyolysis, a condition in which damaged muscles breaks down rapidly, resulting in higher creatinine levels.This condition can increase creatinine levels. Hypothyroidism, a condition where the thyroid glands do not produce enough thyroid hormone.Sickle cell anemia – in this condition kidneys reabsorb less urea and more of it is lost in the urine, resulting in lower BUN.Advanced liver disease, when the liver can’t produce enough urea, resulting in lower BUN levels.Low protein intake, seen in conditions of malnutrition and starvation.Work with your doctor or other health care professional for an accurate diagnosis.Ī BUN/Creatinine ratio lower than normal can be caused by: The causes shown here are commonly associated with low BUN/creatinine. Low BUN/Creatinine RatioĪ low BUN/Creatinine ratio indicates an underlying disease/disorder and will usually be accompanied by the symptoms of this underlying disorder. The normal range for BUN/Creatinine ratio is anywhere between 5 – 20 mg/dL.īUN/Creatinine ratio increases with age, and with decreasing muscle mass. That’s why the BUN/Creatinine ratio can be used to check for issues such as dehydration, kidney injury/disease, gut bleeding, and other problems. So to recap, BUN levels fluctuate, while creatinine is removed at a constant rate and its blood levels are usually stable. That is why blood levels are usually a good indicator of how well your kidneys are working. Ĭreatinine is removed from the body by the kidneys, which filter almost all of it from the blood into the urine, at a fairly constant rate. Creatinine production essentially reflects muscle mass, and because this mass changes little from day to day, creatinine production tends to be fairly constant. It is produced from creatine, a protein that helps generate energy for muscle contractions. Ĭreatinine, on the other hand, is a waste product created from the normal wear and tear of muscles. High urea is an important marker of kidney dysfunction as well. The kidneys can return different amounts of urea into the bloodstream depending on factors such as hydration and blood pressure. Urea is removed by the kidneys, but the rate of removal depends on the needs of the body. A plus sign next to the number “” means that the information is found within the full scientific study rather than the abstract. If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please leave a comment or contact us at that each number in parentheses is a clickable link to peer-reviewed scientific studies. Our goal is to not have a single piece of inaccurate information on this website. They are continually monitored by our internal peer-review process and if we see anyone making material science errors, we don't let them write for us again. Our science team must pass long technical science tests, difficult logical reasoning and reading comprehension tests. Our science team is put through the strictest vetting process in the health industry and we often reject applicants who have written articles for many of the largest health websites that are deemed trustworthy. Our team comprises of trained MDs, PhDs, pharmacists, qualified scientists, and certified health and wellness specialists.Īll of our content is written by scientists and people with a strong science background. We are dedicated to providing the most scientifically valid, unbiased, and comprehensive information on any given topic. We believe that the most accurate information is found directly in the scientific source. SelfDecode has the strictest sourcing guidelines in the health industry and we almost exclusively link to medically peer-reviewed studies, usually on PubMed.
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